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Abstract #4384

A Study on Time Dependency of the Fractional Order Calculus Diffusion Model

Guangyu Dan1,2, Yuxin Zhang3,4, Zheng Zhong1,2, Kaibao Sun1, M. Muge Karaman1,2, Diego Hernando3,4, and Xiaohong Joe Zhou1,2,5
1Center for Magnetic Resonance Research, University of Illinois at Chicago, Chicago, IL, United States, 2Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, 3Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 4Department of Radiology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States, 5Department of Radiology and Neurosurgery, University of Illinois at Chicago, Chicago, IL, United States

Parameters in many diffusion models depend on diffusion time. However, time-dependent diffusion behaviors in the long diffusion time regime have not been well studied because a longer diffusion time would lead to a longer TE, substantially reducing signal-to-noise ratio in conventional spin-echo diffusion pulse sequences. In this study, we employed a STEAM diffusion sequence to investigate the diffusion-time dependence of parameters in a fractional order calculus diffusion model. Our results showed substantial dependence of all diffusion parameters on diffusion times in the range of 100-1000 ms.

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