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Abstract #4385

Delineating the grey matter-white matter interface directly from diffusion MRI data

Dmitri Shastin1,2, Maxime Chamberland1, Greg Parker1, Chantal M. W. Tax1, Kristin Koller1, Khalid Hamandi1,2, William Gray2,3, and Derek Jones1
1School of Psychology, Cardiff University Brain Research Imaging Centre, Cardiff, United Kingdom, 2School of Medicine, Cardiff University Brain Research Imaging Centre, Cardiff, United Kingdom, 3BRAIN Biomedical Research Unit, Cardiff, United Kingdom

Anatomically constrained tractography aims to reduce the number of false positive streamlines by applying anatomically realistic priors. Grey matter-white matter interface is currently extracted based on T1 information requiring the availability of a T1 volume and its accurate co-registration with diffusion MRI data. Here we describe an alternative method based on multi-shell multi-tissue constrained spherical deconvolution that produces the interface without the need for T1. We go ahead and compare our method with the existing one and show a potential application.

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