We proposed a new Diffusion Weighted Imaging (DWI) with T2-based water suppression technique (Wsup-DWI) and additionally combined with synthetic-MRI technique. Our water suppression was achieved by subtracting heavy T2-weighted (long-TE) image from the standard DWI images after correcting signal intensities due to b-value. We demonstrated that hyperintense artifacts due to CSF partial volume effects (PVE) were dramatically suppressed even at lower b-values (b); and quantitative maps of ADC and FA became close to the tissue values due to CSF reduction. Furthermore, fiber tracts became longer for Wsup-DWI data than for standard-DWI data in a tractography with the same condition.
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