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Abstract #4394

A simple phantom for extracting Intravoxel Incoherent Motion (IVIM) model parameters

Erick O Buko1, Afis Ajala1, Jiming Zhang2, and Pei Herng Hor1
1Physics, Texas Center for Superconductivity at University of Houston, Houston, TX, United States, 2Diagnostic and Interventional Radiology, Baylor St. Luke's Medical Center, Houston, TX, United States

We present a simple phantom set-up to model diffusion weighted imaging signal arising from intra-voxel incoherent motion (IVIM). The model provides means to independently control both the perfusion fraction (f) as well as the pseudodiffusion coefficient (Df). Across a range of flow velocities, numerical simulations and phantom experiments confirm that: (a) perfusion fraction (f) is overestimated by traditional analysis approaches such as segmented (S), or oversegmented (OS) methods, but is slightly underestimated by the AS-T2 method; (b) Df increases in proportion to flow velocity, and the estimation of Df is unaffected by the analysis technique.

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