Abstract #4395

Impact of brain and head and neck radiotherapy fixation and coil configuration on tensor-valued dMRI

Patrik Brynolfsson¹, Markus Nilsson², Christian Jamtheim Gustafsson^1,3, Tim Sprenger⁴, Pia C Sundgren^5,6, Lars E Olsson¹, and Filip Szczepankiewicz^7,8

¹Dept. of Translational Medicine, Division of Medical Radiation Physics, Lund University, Lund, Sweden, ²Dept. of Clinical Sciences, Division of Radiology, Lund University, Lund, Sweden, ³Dept. of Hematology, Oncology and Radiation Sciences, Lund University, Lund, Sweden, ⁴MR Applied Science Laboratory Europe, GE Healthcare, Stockholm, Sweden, ⁵Diagnostic Radiology, Clinical Sciences, Lund University, Lund, Sweden, ⁶Lund University Bioimaging Center, Lund University, Lund, Sweden, ⁷Lund University, Lund, Sweden, ⁸Brigham and Women's Hospital, Boston, MA, United States

Brain and head and neck cancer patients need fixation while undergoing radiotherapy, which prevents the use of a dedicated head coil when imaging patients using MRI in radiotherapy setup. We investigate the impact of coil setup on the technical feasibility of tensor-valued diffusion MRI in a radiation therapy setting. Three coil configurations were evaluated with respect to SNR and parameter bias in the resulting parametric maps using Bland-Altman plots. As expected, the coils configured for radiation therapy imposed a penalty on the SNR, but accuracy was not negatively impacted.

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