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Abstract #4395

Impact of brain and head and neck radiotherapy fixation and coil configuration on tensor-valued dMRI

Patrik Brynolfsson1, Markus Nilsson2, Christian Jamtheim Gustafsson1,3, Tim Sprenger4, Pia C Sundgren5,6, Lars E Olsson1, and Filip Szczepankiewicz7,8
1Dept. of Translational Medicine, Division of Medical Radiation Physics, Lund University, Lund, Sweden, 2Dept. of Clinical Sciences, Division of Radiology, Lund University, Lund, Sweden, 3Dept. of Hematology, Oncology and Radiation Sciences, Lund University, Lund, Sweden, 4MR Applied Science Laboratory Europe, GE Healthcare, Stockholm, Sweden, 5Diagnostic Radiology, Clinical Sciences, Lund University, Lund, Sweden, 6Lund University Bioimaging Center, Lund University, Lund, Sweden, 7Lund University, Lund, Sweden, 8Brigham and Women's Hospital, Boston, MA, United States

Brain and head and neck cancer patients need fixation while undergoing radiotherapy, which prevents the use of a dedicated head coil when imaging patients using MRI in radiotherapy setup. We investigate the impact of coil setup on the technical feasibility of tensor-valued diffusion MRI in a radiation therapy setting. Three coil configurations were evaluated with respect to SNR and parameter bias in the resulting parametric maps using Bland-Altman plots. As expected, the coils configured for radiation therapy imposed a penalty on the SNR, but accuracy was not negatively impacted.

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