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Abstract #4419

Quantifying Intra-Soma Diffusion Properties via Spherical Mean Spectrum Imaging

Khoi Minh Huynh1,2, Ye Wu2, Kim-Han Thung2, Sahar Ahmad2, Hoyt Patrick Taylor IV2, Weili Lin2, and Pew-Thian Yap2
1Department of Biomedical Engineering, UNC-Chapel Hill, Chapel Hill, NC, United States, 2Department of Radiology and BRIC, UNC-Chapel Hill, Chapel Hill, NC, United States

We propose a novel model to quantify intra-soma diffusion properties, including volume fractions and kurtosis. The model is flexible, allowing simultaneous modeling of multiple tissue compartments without the need for assumptions on the number of compartments and their diffusivities. We demonstrate that our method provides biologically meaningful contrasts that agree well with histological data.

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