Diffusion-time (∆) dependence in the bi-exponential intra-voxel incoherent motion model of diffusion-weighted imaging (DWI) signal decay is generally not considered. However, by using multi-∆ signal acquisitions, blood flow dynamics across different flow regimes can be accessed. In this study, we use multi-∆ DWI and an adapted velocity autocorrelation model to estimate blood velocity (v), capillary segment length (l) and transvascular water exchange. Human cerebral cortex and white matter (WM) estimates of v (cortex: 1.85 ± 0.21 mms-1; WM: 2.67 ± 1.01 mms-1) and l (cortex: 43.4 ± 19.5 µm; WM: 93.3 ± 51.1 µm) are consistent with literature values.
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