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Abstract #4423

Optimisation of Temporal Diffusion Ratio (TDR) to maximise its potential to map large axons: Insight from simulations

William Richard Warner1, Marco Palombo1, Flavio Dell'Acqua2, and Ivana Drobnjak1
1CMIC, Computer Science Department, University College London, London, United Kingdom, 2NatBrainLab, King's College London, London, United Kingdom

Temporal Diffusion Ratio (TDR) is a novel technique introduced by Dell’Acqua et al. at ISMRM 2019, with potential for mapping areas with large diameter axons in the human brain. We aim to maximise TDR signal in practical applications by optimizing the sequence parameters used. Working in simulation, it is found that the highest TDR signal for a given axon diameter is produced by contrasting signal from sequences with as disparate as possible shapes: a tall/narrow gradient shape should be contrasted with a short/wide gradient to produce the best contrast.

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