Abstract #4424

Single-shell derived tissue signal fraction maps show increased contrast between hippocampal subfields compared to multi-shell analysis.

Benjamin T Newman^1,2, Thijs Dhollander^3,4, and T. Jason Druzgal^1,2

¹Department of Radiology & Medical Imaging, Division of Neuroradiology, University of Virginia Health System, University of Virginia, Charlottesville, VA, United States, ²Brain Institute, University of Virginia, Charlottesville, VA, United States, ³The Florey Department of Neuroscience, University of Melbourne, Melbourne, Australia, ⁴The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia

Recent advances in the analysis of diffusion MRI have allowed for the estimation of 3 tissue compartments in the brain from data with only a single non b=0 shell. There is currently no published quantitative comparison between signal fractions derived from either single- or multi-shell methods. Applying both single-shell analysis and multi-shell analysis to the same dataset shows high b-value single-shell analysis may increase contrast between different hippocampal subfields. While this effect may occur due to differences in microstructure between ROIs it should be a noted factor when applying either model and deserving of further study.

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