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Abstract #4428

Using stimulated echo diffusion MRI to elucidate cellular changes during cell death

Daniel Djayakarsana1,2, Gregory J Czarnota1,2,3, and Colleen Bailey1,2
1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 3Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Morphological changes caused by cellular death alter the movement of water, which diffusion MRI has the potential to detect. Cellular death can be easily isolated with an in vitro model. I find that the ADC, kurtosis and the ball-sphere model showed significant changes between the control and the treated groups. Likely sources of parameter changes are the increased membrane permeability, organelle/macromolecule breakdown and differences in cellular size.

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