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Abstract #4432

Decreased axon water fraction can result from either axonal loss and/or demyelination, reflecting different ex-vivo and in-vivo conditions

Zihan Zhou1, Qiqi Tong1, Qiuping Ding1, Junye Yao1, Hongjian He1, and Jianhui Zhong1,2
1Center for Brain Imaging Science and Technology, Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrumental Science, Zhejiang University, Hangzhou, China, 2School of Medicine and Dentistry, University of Rochester Medical Center, New York, NY, United States

White Matter Tract Integrity (WMTI) is specific to tissue microstructure. However, answers to a question of what a decreased axon water fraction (AWF), a metric of WMTI, reflects seem contradictory among previous in-vivo and ex-vivo studies. To our knowledge, there have been no studies that compare the difference in AWF decline under both ex-vivo and in-vivo conditions. Here we use Monte Carlo (MC) simulation to investigate such question and results show that AWF decline indicated demyelination under ex-vivo conditions while it also related to axonal loss in-vivo besides demyelination. Results highlighted the non-negligible effect of membrane permeability on the difference.

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