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Abstract #4440

Behaviors of high b-value direction-averaged DWI signal decay in human gray matter

Chu-Yu Lee1, In-Young Choi1,2,3, and Phil Lee1,4
1Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States, 2Department of Neurology, University of Kansas Medical Center, Kansas City, KS, United States, 3Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United States, 4Department of Radiology, University of Kansas Medical Center, Kansas City, KS, United States

Neurite microenvironment has been approximated as impermeable, thin cylindrical tubes. This assumption has been validated in human white matter by a power law with the exponent of around 0.5 at b-values above 4000 s/mm2. However, the decay exponent in gray matter deviates from 0.5, suggesting that the cylindrical tube approximation does not apply in gray matter. This study aimed to study the whole-brain gray matter distribution of the decay exponent, and demonstrated an apparent contrast in the decay exponent between cortical gray matter and deep gray matter. This suggests that inherent microstructural differences may exist between these gray matter regions.

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