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Abstract #4441

Detecting the evolving tumor microenvironment with diffusion microstructure modeling: a simulation study

Shu Xing1,2 and Ives R. Levesque1,2,3,4
1Department of Physics, McGill University, Montreal, QC, Canada, 2Medical Physics Unit, McGill University, Montreal, QC, Canada, 3McGill University Health Center Research Institute, Montreal, QC, Canada, 4Department of Oncology, McGill University, Montreal, QC, Canada

Diffusion MRI with microstructure modeling can nominally map voxelwised cell radii and relative cell volume fractions for the entire tumour. This work proposes a model selection method that chooses the most suitable diffusion model among the two microstructural models and the monoexponential ADC model. This technique can potentially distinguish tissue microstructure featuring one or two underlying cell populations, and acellular necrosis. Microstructural parameters were also reliably estimated. These observations suggest the possible differentiation of three tumour microenvironments resulting from cancer therapy.

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