To gain more insight into age-effects on white matter diffusivity, advanced diffusion MRI models attempt to separate the effect of cellular diffusion from extracellular isotropic water movement by modeling the latter as free water (FW). Using these models, increased diffusivity with age is typically attributed to an enlargement of the FW compartment with age. The current study compares the sensitivity of FW to age using two common modeling approaches: single-shell fwDTI and multi-shell NODDI.
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