Abstract #4443

Mapping diffusion in aging white matter: A comparison of two free-water modeling approaches

Jordan A. Chad^1,2, Ofer Pasternak³, and J. Jean Chen^1,2

¹Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada, ²Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States

To gain more insight into age-effects on white matter diffusivity, advanced diffusion MRI models attempt to separate the effect of cellular diffusion from extracellular isotropic water movement by modeling the latter as free water (FW). Using these models, increased diffusivity with age is typically attributed to an enlargement of the FW compartment with age. The current study compares the sensitivity of FW to age using two common modeling approaches: single-shell fwDTI and multi-shell NODDI.

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