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Abstract #4444

What’s the FWAF? A Finite Width Adjustment Factor for the effect of finite pulse duration on the diffusion signal in impermeable cylinders

Nadia A S Smith1, Jessica E Talbott1, Chris A Clark2, and Matt G Hall1,2
1National Physical Laboratory, Teddington, United Kingdom, 2UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom

A common approach to microstructure imaging in diffusion MRI is to fit the signal with a weighted sum of geometric compartments. This approach is widespread but the need for analytical closed-form solutions necessitates highly restrictive assumptions about the underlying physics which are rarely met in practice. In particular, violation of the narrow-pulse approximation is a significant potential source of bias. This abstract investigates the effect of violating the narrow pulse approximation numerically and proposes a simple effect correction factor to reduce apparent bias as a scale factor on q as a function of δ.

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