Apparent exchange rate (AXR) mapping can be used to non-invasively investigate water exchange between the intra- and extracellular compartment, which might yield insight into cell membrane permeability. However, the measured AXR is also significantly influenced by intra- and extracellular water fractions. In this study, using simulations and experiments with yeast cells, we show that – for low cell concentrations – the AXR exhibits only a moderate dependence on the cell concentration, while for high concentrations, a stronger influence of the packing density on AXR occurs so that it becomes more difficult to disentangle these two influencing parameters.
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