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Abstract #4445

Apparent exchange rate (AXR) mapping: Influence of extracellular volume fraction and membrane permeability

Julian Rauch1,2, Tristan Anselm Kuder1, Frederik Bernd Laun3, Karel D. Klika4, Peter Bachert1,2, and Dominik Ludwig1,2
1Department of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Faculty of Physics and Astronomy, Heidelberg University, Heidelberg, Germany, 3Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 4Molecular Structure Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany

Apparent exchange rate (AXR) mapping can be used to non-invasively investigate water exchange between the intra- and extracellular compartment, which might yield insight into cell membrane permeability. However, the measured AXR is also significantly influenced by intra- and extracellular water fractions. In this study, using simulations and experiments with yeast cells, we show that – for low cell concentrations – the AXR exhibits only a moderate dependence on the cell concentration, while for high concentrations, a stronger influence of the packing density on AXR occurs so that it becomes more difficult to disentangle these two influencing parameters.

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