We used the VERDICT framework to find clinically useful microstructural models to characterize vasculature in brain tumors. We correlated the vascular fractions, estimated by all possible three-compartment models, with perfusion MRI metrics (plasma volume and cerebral blood volume) derived from independent measurements on the same patients. The models with the strongest correlation with the perfusion MRI and clinical data incorporate spherical restriction for the intracellular compartment, isotropic diffusion for the extracellular compartment, and isotropically hindered or restricted pseudo-diffusion for the vascular compartment.
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