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Abstract #4449

Diffusion Tensor Distribution (DTD) MRI Reimagined

Magdoom Kulam Najmudeen1, Michal E Komlosh1,2, Dario Gasbarra3, and Peter J Basser1
1SQITS/NICHD, National Institute of Health, Bethesda, MD, United States, 2The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States, 3University of Helsinki, Helsinki, Finland

A new DTD imaging method is presented with novel data acquisition schemes for higher rank b-matrices, and analysis pipeline to estimate the mean and covariance of diffusion tensor. The developed pulse sequence is simple, easy to implement with well defined diffusion, mixing and pulsed gradient dwell times and immune to concomitant fields. The method is validated using PDMS phantom and excised rat brain tissue. Estimated DTD was used to compute the microscopic FA and AD. The phantom results agreed as expected with zero FA and uFA and accurate AD. The approach was able to capture the heterogeneity in the brain.

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