Abstract #4453

Imaging meningioma tumor microstructure: a comparison between quantitative histopathology and high-resolution diffusion tensor imaging

Jan Brabec¹, Filip Szczepankiewicz^2,3,4, Elisabet Englund⁵, Johan Bengzon⁶, Linda Knutsson^1,7, Carl-Fredrik Westin^2,3, Pia Sundgren^4,8, and Markus Nilsson⁴

¹Clinical Sciences Lund, Medical Radiation Physics, Lund University, Lund, Sweden, ²Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States, ³Harvard Medical School, Boston, MA, United States, ⁴Clinical Sciences Lund, Diagnostic Radiology, Lund University, Lund, Sweden, ⁵Clinical Sciences, Oncology and Pathology, Lund University, Lund, Sweden, ⁶Clinical Sciences, Neurosurgery, Lund University, Lund, Sweden, ⁷Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁸Lund University Bioimaging Center, Lund University, Lund, Sweden

We explore anisotropy of meningioma tumors by using structure tensor analysis of histological images and high-resolution diffusion MRI scans. We observed a good visual agreement between the structure- and diffusion-based anisotropy measures, but a more modest quantitative agreement. The results highlight the need to image microscopic rather than voxel-level fractional anisotropy in meningioma tumors.

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