Abstract #4460

Influence of WM fibre orientation on gradient-echo derived tissue parameters

Tonima S Ali¹, Elisabeth C van der Voort^1,2, and Markus Barth^3,4

¹University of Queensland, Brisbane, Australia, ²Eindhoven University of Technology, Eindhoven, Netherlands, ³The University of Queensland, University of Queensland, Brisbane, Australia, ⁴The ARC Training Centre for Innovation in Biomedical Imaging Technology, University of Queensland, Brisbane, Australia

This study investigates the effect of white matter fibre orientation with respect to main magnetic field on gradient-echo (GRE) derived tissue phase, susceptibility, magnetization transfer ratio, R2* and water fraction of myelin water compartments. Spherical deconvolution is used to identify multiple fibre bundles within each imaging voxel. We observed that these GRE derived parameters show moderate sensitivity towards the changes in fibre orientations. Using bi- instead of mono-exponential fitting, it additionally showed that myelin R2* seems more sensitive to the fibre orientation than previously anticipated.

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