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Abstract #4461

Preliminary study of diffusion encoding scheme for double diffusion encoding in clinical application on 3T.

Masanori Ozaki1, Hiroshi Kusahara2, Masahiro Abe2, Masaaki Hori3, Koji Kamagata4, and Shigeki Aoki4
1Research and Development Center, Canon Medical Systems Corporation, Kanagawa, Japan, 2Advanced MRI development PJ Team, Canon Medical Systems Corporation, Kanagawa, Japan, 3Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan, 4Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan

Double diffusion encoding (DDE) can measure the microscopic anisotropy (μFA), however one of problems for clinical application is that the acquisition time is prolonged due to the many diffusion encoding patterns necessary. Recently, DDE with a reduced number of acquisitions has been proposed as a solution and been validated as a solution at 9.4T. The aim of this study is to validate the proposed solution for clinical application on 3T clinical scanners. Our results show that our proposed solution can obtain more accurate μFA than previous reported solutions on 3T clinical scanners.

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