Abstract #4461

Preliminary study of diffusion encoding scheme for double diffusion encoding in clinical application on 3T.

Masanori Ozaki¹, Hiroshi Kusahara², Masahiro Abe², Masaaki Hori³, Koji Kamagata⁴, and Shigeki Aoki⁴

¹Research and Development Center, Canon Medical Systems Corporation, Kanagawa, Japan, ²Advanced MRI development PJ Team, Canon Medical Systems Corporation, Kanagawa, Japan, ³Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan, ⁴Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan

Double diffusion encoding (DDE) can measure the microscopic anisotropy (μFA), however one of problems for clinical application is that the acquisition time is prolonged due to the many diffusion encoding patterns necessary. Recently, DDE with a reduced number of acquisitions has been proposed as a solution and been validated as a solution at 9.4T. The aim of this study is to validate the proposed solution for clinical application on 3T clinical scanners. Our results show that our proposed solution can obtain more accurate μFA than previous reported solutions on 3T clinical scanners.

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