Abstract #4464

Diffusion Tensor Tractography of Tendons as a Tool for Assessing MRgFUS Ablation

William Chu Kwan¹, Warren Foltz², Ben Keunen¹, Matt Walker³, Karolina Piorkowska¹, Adam Waspe¹, and James Drake⁴

¹Center for Image Guided Innovation and Therapeutic Intervention, Hospital for Sick Children, Toronto, ON, Canada, ²Radiation Oncology, University Health Network, Toronto, ON, Canada, ³Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁴Department of Surgery, Center for Image Guided Innovation and Therapeutic Intervention, Hospital for Sick Children, Toronto, ON, Canada

MRgFUS ablation of tendons is a promising treatment to disrupt tendons in conditions such as musculotendinous contractures. In this study, DTI and tractography were proposed as tools to assess tendons before and after MRgFUS ablation, providing a quantitative, directional, and visual assessment of tendon tract architecture and integrity. Diffusivity parameters (FA and ADC) changed in accordance to the tendon fascicle integrity. Fiber tractography visually delineated healthy tendon fascicles and confirmed tract disruptions at the same location as registered with b₀ and T1-weighted images. This study demonstrates the potential for DTI and tractography as assessment tools for MRgFUS ablation treatments.

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