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Abstract #4465

A novel ex vivo structural connectome atlas of the C57Bl6 mouse brain using ultra-high field diffusion MRI at 17.2T

Ivy Uszynski1, Roxane Golgolab1, David A. Barrière1, Tomokazu Tsurugizawa1, Michel Simonneau2,3,4,5, Luisa Ciobanu1, and Cyril Poupon1
1NeuroSpin, CEA, Gif-sur-Yvette, France, 2Centre Psychiatrie & Neurosciences, INSERM U894, Paris, France, 3Ecole Normale Supérieure Paris-Saclay & LAC-CNRS, Institut d’Alembert, Cachan, France, 4LBPA, Institut d’Alembert, Ecole Normale Supérieure Paris-Saclay, Université Paris-Saclay, Cachan, France, 5Département de Biologie, Ecole Normale Supérieure Paris-Saclay, Université Paris-Saclay, Cachan, France

Diffusion MRI is a powerful tool to investigate the structural connectivity of the brain. Ultra-high field preclinical MRI systems are equipped with strong gradients that allow to reach higher spatial and angular resolutions in animal models, enabling to segment white matter bundles in a similar way to what was achieved in humans. In this study, we propose to adapt the clustering approach of Guevara to rodents to establish a novel atlas of the connectivity of C57BI6 mice brains. 3D Hybrid diffusion imaging was performed ex-vivo allowing the reconstruction of a novel white matter atlas including 25 well-described fiber bundles.

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