The ability of tractography methods to discern between different fiber populations in the presence of challenging anatomical architectures remains limited, and it is hampered by the low spatial resolution achievable by diffusion MRI (dMRI). As a result, tractography often fails to reliably reconstruct some major white matter connections of the human brain. Here we incorporate high-resolution ex-vivo dMRI into the tractography process to understand whether this additional information can improve tractography results.
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