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Abstract #4468

Diffusion MRI analysis of complex fiber configurations in human brain white matter and cortex

Szabolcs David1, Hamed Y Mesri1, Fenghua Guo1, Alexander Leemans1, and Alberto de Luca1
1Image Sciences Institute, UMC Utrecht, Utrecht, Netherlands

Fiber configurations in the human brain white matter and cortex are dominant with multiple orientations. In this work, we investigated the prevalence of crossing fibers in the brain, utilizing the latest multi-shell multi tissue (MSMT) constrained spherical deconvolution (CSD) method to analyze diffusion MRI data from the Human Connectome Project (HCP). Voxel-wise number of fiber orientation (NuFO) was calculated from 56 subjects, using the Generalized Richardson Lucy (GRL) framework, which offers robust fiber orientation distribution (FOD) estimation. Our results suggest that 83% of the voxels have at least one and 37% of the voxels have at least two fiber orientations.

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