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Abstract #4469

Does the intensity inhomogeneity field in diffusion MRI data affect constrained spherical deconvolution results?

Alberto De Luca1, Hamed Yousefi Mesri1, Szabolcs David1, Martijn Froeling2, and Alexander Leemans1
1Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands

The correction for the intensity inhomogeneity field (IIF) is becoming de-facto a pre-processing step in diffusion MRI, but its effect on CSD remains unclear. In this study, we investigated the fundamental effects of the IIF on CSD and the effectiveness of corrections based on a tool commonly applied to structural MRI (N4ITK). We show that the IIF modulates the amplitude of the fiber orientation distribution (FOD), influencing not only the estimation of the response function, but also subsequent uses of the FOD amplitude, as tractography termination criteria or the estimation of the number of fibers (NuFO).

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