The correction for the intensity inhomogeneity field (IIF) is becoming de-facto a pre-processing step in diffusion MRI, but its effect on CSD remains unclear. In this study, we investigated the fundamental effects of the IIF on CSD and the effectiveness of corrections based on a tool commonly applied to structural MRI (N4ITK). We show that the IIF modulates the amplitude of the fiber orientation distribution (FOD), influencing not only the estimation of the response function, but also subsequent uses of the FOD amplitude, as tractography termination criteria or the estimation of the number of fibers (NuFO).
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