Abstract #4476

Longitudinal white matter changes in the callosal subsections in Parkinson’s Disease using connectivity-based parcellation.

Jingjing Wu¹, Xiaoujun Guan¹, Tao Guo¹, Cheng Zhou¹, Ting Gao², Peiyu Huang¹, Xiaojun Xu¹, and Minming Zhang¹

¹Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, ²Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

Corpus callosum (CC) is the most important association fiber intrinsically connecting with different cortical regions. Studies reported the CC and its subsections could be used to differentiate different phenotypes in PD, PD and PDS. In this study, 39 PD patients with a mean time interval of 21m and 82 NC were recruited. We segmented the whole CC into five subsections according to their functional connectivity with predefined cortices. As a result, we observed that the microstructure and structure were fairly preserved in PD at baseline, but widespread changes occur in the corpus callosum during PD evolvement.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.