Corpus callosum (CC) is the most important association fiber intrinsically connecting with different cortical regions. Studies reported the CC and its subsections could be used to differentiate different phenotypes in PD, PD and PDS. In this study, 39 PD patients with a mean time interval of 21m and 82 NC were recruited. We segmented the whole CC into five subsections according to their functional connectivity with predefined cortices. As a result, we observed that the microstructure and structure were fairly preserved in PD at baseline, but widespread changes occur in the corpus callosum during PD evolvement.