We propose to study whole-brain white matter connectivity differences between females and males using diffusion MRI (dMRI) tractography. We leverage a well-established data-driven fiber clustering pipeline and a novel suprathreshold fiber cluster statistical method. We study a large cohort of 707 healthy adult subjects from the Human Connectome Project. We find multiple fiber tracts that are significantly different between the female and male groups in terms of the fractional anisotropy and/or the trace measures of the fiber tracts. These tracts include the corticospinal tract, the arcuate fasciculus, and the corpus callosum tract.