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Abstract #4477

Gender differences in brain white matter discovered by whole brain suprathreshold fiber cluster statistics

Fan Zhang1, Suheyla Cetin-Karayumak1, Yang Song2, Weidong Cai3, James J Levitt1, Nikos Makris1, Carl-Fredrik Westin1, and Lauren J O'Donnell1
1Harvard Medical School, Boston, MA, United States, 2The University of New South Wales, Sydney, Australia, 3The University of Sydney, Sydney, Australia

We propose to study whole-brain white matter connectivity differences between females and males using diffusion MRI (dMRI) tractography. We leverage a well-established data-driven fiber clustering pipeline and a novel suprathreshold fiber cluster statistical method. We study a large cohort of 707 healthy adult subjects from the Human Connectome Project. We find multiple fiber tracts that are significantly different between the female and male groups in terms of the fractional anisotropy and/or the trace measures of the fiber tracts. These tracts include the corticospinal tract, the arcuate fasciculus, and the corpus callosum tract.

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