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Abstract #4478

MODELLING NEURAL EXCITABILITY OF REALISTIC DTI-DERIVED AXON TRAJECTORIES

Sulagna Sahu1, Munish Chauhan1, Saurav Zaman Khan Sajib1, Stephen Helms Tillery1, Vikram D. Kodibagkar1, and Rosalind J. Sadleir1
1Arizona State University, Tempe, AZ, United States

Studying neural activation patterns is critical in the understanding of neuromodulation in transcranial electrical stimulation methods (TES). This research focuses on simulations of neural excitability of a realistic axon model obtained from DTI tractography of the trigeminal nerve, in comparison to a linear axon model obtained from literature, in presence of induced electric fields found from realistic FEM (finite element method) modelling of TES. The differences observed highlight the need for use of realistic trajectories in neural simulations and provide means for patient specific personalized studies.

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