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Abstract #4482

Detecting neuronal connectivity using diffusion tensor imaging in a Parkinson`s disease mouse basal ganglia using 9.4T MRI

Sang-Jin Im1 and Hyeon-Man Baek1
1Gachon university, Incheon, Korea, Republic of

Parkinson's disease (PD) is a neurodegenerative disorder that affects motor and cognition, resulting from dopaminergic cell death in substantia nigra (SN). Basal ganglia, a neural circuit involved in executive functions such as motor control and have been studied extensively in PD mouse models. Mouse brain tractography using MRI have seen increasing use to study neural networks but more comprehensive analysis is needed to establish a stronger consensus. The purpose of this study is to provide a comprehensive analysis of basal ganglia neuronal connectivity in control and PD mouse models.

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