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Abstract #4487

Does introduction of priors improve reliability to segment hyperdirect connections using tractography for Deep Brain Stimulation ?

Tristan MOREAU1, Maxime PERALTA1, John BAXTER1, and Pierre JANNIN1
1UMR 1099 LTSI, RENNES, France

A better knowledge of subthalamic nucleus connections could help predict the clinical outcome of deep brain stimulation in the context of Parkinson’s disease. However, diffusion weighted images used in clinical context are generally of poor resolution. In this study, we compared a whole brain versus an a-priori-based tractography method in order to segment hyperdirect connections linking subthalamic nucleus to cortex on normal controls acquired in clinical context. In systematically comparing our hyperdirect connections segmentation results with high resolution data set, we showed better reliability when using the a-priori-based tractography compared to the whole-brain method.

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