We evaluated the performance of diffusion MRI (dMRI) acquisition with simultaneous multi-slice (SMS) readout-segmented echo-planar imaging (rs-EPI) in measuring the uncinate fasciculus, which is typically affected by susceptibility-induced distortion or signal dropout. We found that SMS rs-EPI data provides a larger number of streamlines supported by dMRI data and larger fractional anisotropy in uncinate, as compared to conventional SMS single-shot EPI data. However, such an advantage was not consistent across subjects in the forceps major. Taken together, our results demonstrate that dMRI acquisition with SMS rs-EPI has advantages in measuring specific white matter tracts affected by susceptibility-induced artifacts.
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