The ODF-Fingerprinting method has proven to be successful in improving detection of fiber pairs with small crossing fibers [1]. We evaluated the performance of ODF-Fingerprinting and other algorithms used to detect fiber directions, to determine whether the clinical application contains the same success that was experienced in a healthy control. The performance of these competing algorithms was examined in a healthy control and post-operative scan of a tumor patient. With the success of ODF-Fingerprinting in comparison to other algorithms, we hope that the application of this algorithm will lead to improved neurosurgical precision.