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Abstract #4484

Aligning Shapes of Along-tract Diffusion Profiles across Populations

David Soobin Lee1, Antoni Kubicki1, Ashish Kaul Sahib1, Katherine L Narr1, and Shantanu H Joshi1
1UCLA, Los Angeles, CA, United States

Various tools exist to extract diffusion measures from tract profiles. However, they lack the precision in terms of statistical analysis since the tract shapes are registered to a common template. Although this analysis leads to meaningful results, we postulate that there is a significant geometric information in the along-tract diffusion profiles that is unaccounted for. Here we propose a novel method for aligning shapes of diffusion profiles across populations. This method offers improved matching and statistical analysis of along-tract diffusion profiles. Furthermore, this method could be used to perform multivariate statistical analysis of along-tract diffusion profiles in an invariant manner.

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