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Abstract #4494

Structural connectome of autonomic and sensory brainstem nuclei in humans based on 7 Tesla high spatial and angular resolution diffusion imaging

KAVITA SINGH1, María Guadalupe García-Gomar1, Jeffery P Staab2,3, Simone Cauzzo4, Iole Indovina5,6, and Marta Bianciardi1
1Brainstem Imaging Laboratory, Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, 2Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States, 3Department of Otolaryngology, Head and neck Surgery, Mayo clinic, Rochester, MN, United States, 4Institute of Life Sciences, Sant'Anna School of Advanced Studies, Pisa, Italy, 5Laboratory of neuromotor physiology, IRCCS, Santa Lucia Foundation, Rome, Italy, 6Centre of SpaceBiomedicine, University of Rome for Vergata, Rome, Italy

With the advancement of imaging technologies and signal processing tools, ample progress has been made in cortical and sub-cortical brain structural connectivity mapping; however, this is still missing in living humans for brainstem nuclei. Through high spatial-resolution 7 Tesla HARDI MRI and a recently developed probabilistic brainstem nuclei atlas, we built a structural connectome of autonomic and sensory brainstem nuclei in living humans. Interestingly, our connectome corresponded well with established non-human connectivity data. We foresee this connectome as basis for structural and functional studies of autonomic and sensory circuits in health and disease.

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