Abstract #4495

3D-printed phantom for validating diffusion MRI models

Michael Woletz¹, Franziska Gantner^2,3, Benedikt Hager⁴, Peter Gruber^2,3, Siawoosh Mohammadi^5,6, Zoltan Nagy⁷, Aleksandr Ovsianikov^2,3, and Christian Windischberger¹

¹Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, ²Institute of Materials Science and Technology, Technical University Vienna, Vienna, Austria, ³Austrian Cluster for Tissue Regeneration, Vienna, Austria, ⁴Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ⁵Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ⁶Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ⁷Laboratory for Social and Neural Systems Research (SNS Lab), University of Zurich, Zurich, Switzerland

Here we show the first DTI phantom manufactured by advanced high-resolution 3D-printing methods. The phantom consists of hollow, 12μm thin, liquid filled channels, that can be constructed in arbitrary configurations, ideally suited for validating diffusion sequences and analysis models. A simple configuration with orthogonal channel directions is presented. Diffusion weighted images were acquired and a diffusion tensor model employed. The main direction of the resulting tensors is accurately able to capture the directions of the channels with an average fractional anisotropy of 0.46. This method for creating diffusion phantoms will help to test and validate different models in the future.

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