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Abstract #4495

3D-printed phantom for validating diffusion MRI models

Michael Woletz1, Franziska Gantner2,3, Benedikt Hager4, Peter Gruber2,3, Siawoosh Mohammadi5,6, Zoltan Nagy7, Aleksandr Ovsianikov2,3, and Christian Windischberger1
1Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, 2Institute of Materials Science and Technology, Technical University Vienna, Vienna, Austria, 3Austrian Cluster for Tissue Regeneration, Vienna, Austria, 4Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 5Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 6Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 7Laboratory for Social and Neural Systems Research (SNS Lab), University of Zurich, Zurich, Switzerland

Here we show the first DTI phantom manufactured by advanced high-resolution 3D-printing methods. The phantom consists of hollow, 12μm thin, liquid filled channels, that can be constructed in arbitrary configurations, ideally suited for validating diffusion sequences and analysis models. A simple configuration with orthogonal channel directions is presented. Diffusion weighted images were acquired and a diffusion tensor model employed. The main direction of the resulting tensors is accurately able to capture the directions of the channels with an average fractional anisotropy of 0.46. This method for creating diffusion phantoms will help to test and validate different models in the future.

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