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Abstract #4496

Water diffusion pore imaging on a 14.1 T spectrometer using glass capillary phantoms in the presence of extraporal fluid

Dominik Ludwig1,2, Frederik Bernd Laun3, Karel D. Klika4, Mark Edward Ladd1,2,5, Peter Bachert1,2, and Tristan Anselm Kuder1
1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Faculty of Physics and Astronomy, Heidelberg University, Heidelberg, Germany, 3Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 4Molecular Structure Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany, 5Faculty of Medicine, Heidelberg University, Heidelberg, Germany

Diffusion pore imaging (DPI) can be used to retrieve the pore space function of arbitrary closed pores. In this study we show that DPI of glass capillaries is possible even under difficult experimental conditions. By separating the long gradient into a CPMG-like gradient echo train and matching the magnetic susceptibility, it was possible to acquire diffraction patterns of glass capillaries that were placed orthogonal to the main magnetic field. Furthermore, the feasibility of doing DPI in the presence of water outside the pores was demonstrated for the first time.

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