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Abstract #4497

Validation of NMR transient subdiffusion in controlled samplesĀ 

Silvia Capuani1, Fabio Micalizzi2, Simona Sennato3, Giulio Costantini3, Roberto Matassa4, Dante Rotili5, Lorenzo Correale2, Francesca Giuffrida2, Annalisa Caligiuri2, Giovanni Familiari4, and Andrea Gabrielli3
1Physics Dpt. Sapienza, CNR ISC, Rome, Italy, 2Physics Dpt., Sapienza University of Rome, Rome, Italy, 3Physics Dpt. Sapienza Roma, CNR ISC, Rome, Italy, 4Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy, 5Drug chemistry and technology department, Sapienza University of Rome, Rome, Italy

The quantification of transient anomalous diffusion (tAD) parameters by NMR could provide higher sensitivity, resolution and complementary detailed information for detecting early changes due to pathological conditions than the conventional metric does. However, there are some questions and controversial issues which prevent the take-off of tAD NMR investigations in soft condensed matter and medical diagnostic field. To overcome these obstacles, we planned to investigate the potential and limits of NMR subdiffusion in calibration standards characterized by porous structured materials and diffusing probes matching or not characteristics length-scales of the porous matrix.

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