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Abstract #4498

Phantom validation of diffusion weighted T2- and T2*-relaxometry EPI sequences

Yu Zidan1,2, Jelle Veraart1,2, Gregory Lemberskiy1,2, Ying-Chia Lin1,2, Tiejun E. Zhao3, Martijn Cloos1,2, Dan Iosifescu4,5, and Steven H. Baete1,2
1Center for Biomedical Imaging, Dept. of Radiology, NYU School of Medicine, New York, NY, United States, 2Center for Advanced Imaging Innovation and Research (CAI2R), NYU School of Medicine, New York, NY, United States, 3Siemens Medical Solutions, New York, NY, United States, 4Dept. of Psychiatry, NYU School of Medicine, New York, NY, United States, 5Clinical Research Division, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, United States

Combination of diffusion weighted MRI with orthogonal measures such as T2- or T2*-weighting has been proposed to overcome the fit degeneracy found in microstructure modeling of diffusion signals. However, the repetition of diffusion measurements at different TE leads to unacceptably long acquisition times, hindering clinical applicability of this approach. Here, we propose accelerated acquisitions using diffusion weighted multi-spin and multi-gradient echo trains which sample the signal at several TEs after a standard diffusion encoding spin echo. In the current configurations these sequences speed up the acquisitions by 2.6x or 3.6x respectively. We validate these approaches on a phantom.

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