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Abstract #4499

Sensitivity Gain from Multi-Echo Acquisitions in Ex-Vivo Diffusion Imaging: Numerical Simulations and Experimental Verification

Cornelius Eichner1, Michael Paquette1, Toralf Mildner2, Torsten Schlumm2, Catherine Crockford3, Roman Wittig3, Carsten Jäger4, Markus Morawski4, Harald E. Möller2, Angela D. Friederici1, and Alfred Anwander1
1Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2NMR Unit, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 3Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany, 4Paul Flechsig Institute of Brain Research, University Leipzig, Leipzig, Germany

Ex-vivo dMRI acquisitions achieve very high resolutions from increased SNR at the cost of prolonged scan times. Due to highly-segmented acquisition strategies, the ex-vivo dMRI signal is often not fully decayed when signal encoding progresses. Using numerical simulations and real-dMRI data from a wild chimpanzee, we show that this circumstance can be effectively employed using an optimized noise informed combination of multi-echo acquisitions from segmented EPI trains. The additional sampling comes at a small price and leads to increased SNR and a general reduction of signal bias.

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