Abstract #4500

Characterization of orientation dispersion’s impact on diffusion kurtosis and NODDI using an axon-mimetic 3D printed phantom

Tristan K. Kuehn^1,2, Farah N. Mushtaha², Omar El-Deeb³, Amanda Moehring³, Corey A. Baron^1,2,4, and Ali R. Khan^1,2,4,5

¹School of Biomedical Engineering, Western University, London, ON, Canada, ²Centre for Functional and Metabolic Mapping, Robarts Research Institute, Western University, London, ON, Canada, ³Department of Biology, Western University, London, ON, Canada, ⁴Department of Medical Biophysics, Western University, London, ON, Canada, ⁵The Brain and Mind Institute, Western University, London, ON, Canada

Existing phantoms used to validate diffusion MRI models of white matter microstructure struggle to represent the complex fibre configurations found in vivo. Here we demonstrate a 3D printed phantom that realizes several complex fibre configurations inexpensively. We prepare a set of phantoms and use them to characterize the change in diffusion MRI model parameters with fibre curvature and crossing fibres. Most parameters computed by DTI, kurtosis, and NODDI had relationships with fibre crossing angle. These phantoms are a promising tool for evaluating the effect of orientation dispersion on diffusion MRI models of white matter.

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