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Abstract #4505

Validation of Diffusion Propagator Imaging measures in White Matter using Histology

Madhura Baxi1,2, Lipeng Ning2, Suheyla Cetin-Karayumak2, Marek Kubicki2,3, and Yogesh Rathi2,3
1Graduate Program for Neuroscience, Boston University, Boston, MA, United States, 2Psychiatry Neuroimaging Lab, HMS, BWH, Boston, MA, United States, 3Department of Psychiatry, MGH, Boston, MA, United States

This study is the first attempt towards histological validation of three advanced diffusion MRI measures derived from the 3D diffusion propagator in white matter tissue: i) return-to-origin-probability (RTOP), ii) return-to-axis-probability (RTAP) and iii) mean squared displacement (MSD), using ex-vivo cat spinal cord tissue. We compared these dMRI measures voxel-wise with the underlying histological properties of the tissue. RTOP and RTAP were found to be significantly correlated with the following biological characteristics: i) Number of axons, ii) Myelin volume fraction and iii) Restricted water fraction, showing that the diffusion propagator imaging measures are sensitive to the underlying white matter microstructural properties.

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