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Abstract #4506

Fundamental Cell Biology Properties Underlying In Vivo DWI

Brendan Moloney1, Eric M. Baker1, Xin Li1, Erin W. Gilbert2, and Charles S. Springer, Jr.1
1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, 2Surgery, Oregon Health & Science University, Portland, OR, United States

With cellular ensembles featuring stochastic [“Voronoi”] geometries, Monte Carlo random walk simulated DWI b-space decays exhibit sensitivity to cell biology parameters measuring membrane Na+,K+‑ATPase [NKA] activity, cell density, ρ, and voxel average cell volume, <V>. Furthermore, the simulations matching disparate in vivo tissue [murine xenograft colorectal cancer, human cerebral cortex, and human bladder] experimental b‑space decays have parameters [cellular water efflux rate constant <kio>, ρ, and <V>] in near absolute agreement with the most pertinent literature. Inspecting the common, empirical early decay measure, ADC, of these simulations provides insights into acute and chronic tissue property changes in vivo.

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