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Abstract #4507

Co-electrospun spinal cord phantom for diffusion MRI

Fenglei Zhou1,2, Francesco Grussu1,3, Zhanxiong Li4, and Geoff Parker1,5
1Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 2School of Pharmacy, University College London, London, United Kingdom, 3Queen Square MS Centre, Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 4College of Textile and Clothing Engineering, Soochow University, Suzhou, China, 5Bioxydyn Limited, Manchester, United Kingdom

A spinal cord-mimicking fibre phantom was developed to evaluate its potential for validating dMRI. Microfibres were co-electrospun with two polymer solutions and characterized by SEM. The phantom comprised two material samples designed with 0o and 90o crossings. SEM revealed that fibres were uniaxially aligned and hollow, having similar sizes to spinal cord axons. Diffusion tensor analysis of a ZOOM dMRI acquisition demonstrated the difference in alignment of the two samples. Diffusion kurtosis analysis demonstrated differences in axial and radial diffusion restriction, with parameter values consistent with published spinal cord data. Relaxation time constants were similar in two samples.

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