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Abstract #4519

Fourier analysis of dynamic diffusion changes during cardiac cycle in idiopathic normal pressure hydrocephalus

Yuya Yasuda1, Tosiaki Miyati1, Naoki Ohno1, Mitsuhito Mase2, Ryo Yagawa1, Rika Saito1, Masatomo Uehara1, Harumasa Kasai2, Yuta Shibamoto2, and Satoshi Kobayashi1
1Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan, 2Nagoya City University Hospital, Nagoya, Japan

In this study, we evaluated the frequency characteristics of the apparent diffusion coefficient (ADC) wave form in the cardiac cycle of the brain in idiopathic normal pressure hydrocephalus (iNPH). iNPH is associated with higher ADC amplitude with a wide frequency range. The Fourier analysis of ADC change in the cardiac cycle in iNPH makes it possible to noninvasively obtain a more detailed information regarding the intracranial state in iNPH.

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