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Abstract #4520

Which frontal white matter pathways mediate executive decline in healthy ageing? 

Anoushka Leslie1, Ahmad Beyh1,2, Marco Catani3, Flavio Dell'Acqua3, Ceriesse Gunasinghe4, Henrietta Howells5, Richard Parker6, Andy Simmons1, Michel Thiebaut de Schotten7,8, Steve Williams1, and Mitul Mehta1
1Department of Neuroimaging, King's College London, London, United Kingdom, 2NatBrainLab, King's College London, London, United Kingdom, 3Natbrainlab, Department of Neuroimaging, King's College London, London, United Kingdom, 4Department of Psychological Medicine, King's College London, London, United Kingdom, 5Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Universita degli studi di Milano, Milano, Italy, 6IXICO plc, London, United Kingdom, 7Groupe d’Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives-UMR 5293, Universite de Bordeaux, Bordeaux, France, 8Brain Connectivity and Behaviour Laboratory, BCBlab, Sorbonne Universities, Paris, France

This study aimed to expand our understanding of how changes to frontal white matter pathways might influence executive decline in healthy ageing. We selected three cognitive components of executive function, attention, spatial working memory and planning and predicted that changes to microstructure of the cingulum, IFOF and SLFI -III would play a mediatory role in age related cognitive decline of 86 healthy adults. Contrary to our predictions, no mediation effects were found within the proposed tract - task groupings. Instead, during exploratory analysis, HMOA of the left uncinate demonstrated a small to medium indirect effect on age-related decline in planning performance.

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