Abstract #4521

Increased non-Gaussian subdiffusion in white matter is associated with increased longitudinal blood pressure exposure in adults at midlife

Carson Ingo^1,2, Shawn Kurian³, James Higgins⁴, Lisanne Jenkins⁵, Donald Lloyd-Jones⁶, and Farzaneh Sorond¹

¹Department of Neurology, Northwestern University, Chicago, IL, United States, ²Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, United States, ³Department of Neurology, Chicago, IL, United States, ⁴Department of Radiology, Northwestern University, Chicago, IL, United States, ⁵Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, United States, ⁶Department of Preventative Medicine, Northwestern University, Chicago, IL, United States

The increased presence of non-Gaussian subdiffusive dynamics, possibly reflecting the presence of increased neuronal and glial microstructural heterogeneity, is sensitive increased vascular risk exposure, which was not observed with traditional DTI metrics such as FA.

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