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Abstract #4522

Along-tract correlation analysis of diffusion metrics and white matter lesions in a 70-year old birth cohort

Carole Hélène Sudre1,2, Chiara Maffei3, Josephine Barnes2, David Thomas2, David Cash2, Tom Parker2, Chris Lane2, Marcus Richards2, Hui Zhang2, Sebastien Ourselin1, Jonathan Schott2, Anastasia Yendiki3, and M. Jorge Cardoso1
1King's College London, London, United Kingdom, 2University College London, London, United Kingdom, 3Massachusetts General Hospital, Boston, MA, United States

In a population of 260 elderly individuals presenting white matter hyperintensities of presumed vascular origin, lesion profile along reconstructed tracts correlated strongly with diffusion metrics obtained from multishell acquisition (notably intracellular volume fraction, orientation dispersion index, axial radial and mean kurtosis). Results appeared stronger when the tractography was performed using data from the highest b-value. Furthermore, changes to the diffusion signal was observed consistently on the reconstructed tracts at the vicinity of the lesions potentially indicative of tissue vulnerability beyond the lesion border identified from FLAIR images.

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