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Abstract #4523

Microstructural and structural connectivity alterations in dexmedetomidine-induced loss of consciousness

Timo Roine1,2, Oskari Kantonen3, Jaakko Langsjö3,4, Kimmo Kaskinoro5, Roosa Kallionpää2,5,6, Annalotta Scheinin3,5, Katja Valli2,5,6,7, Timo Laitio5, Antti Revonsuo2,6,7, and Harry Scheinin3,5,8
1Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland, 2Turku Brain and Mind Center, University of Turku, Turku, Finland, 3Turku PET Centre, University of Turku and the Hospital District of Southwest Finland, Turku, Finland, 4Department of Intensive Care, Tampere University Hospital, Tampere, Finland, 5Division of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, University of Turku, Turku, Finland, 6Department of Psychology and Speech-Language Pathology, University of Turku, Turku, Finland, 7Department of Cognitive Neuroscience and Philosophy, School of Bioscience, University of Skövde, Skövde, Sweden, 8Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland

We used diffusion MRI to investigate brain microstructure and structural connectivity in 10 healthy subjects before and during dexmedetomidine-induced loss of consciousness. We found rapid local changes both in the microstructural properties and in the structural brain connectivity networks, most prominently in the left angular gyrus and its connections indicating possible involvement of the area in consciousness. Moreover, our results indicate that conventional high b-value diffusion MRI acquisitions, in addition to sequences specifically designed to capture functional changes, are sensitive to at least major brain state changes.

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