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Abstract #4527

Tractography based organization of the hyperdirect pathway to the subthalamic area in HCP subjects and parkinsonian patients

Gizem Temiz1, Sophie Sébille1, Chantal François1, Eric Bardinet1, and Carine Karachi1,2
1CENIR, Institut du Cerveau et de la Moelle Epinière, Paris, France, 2AP-HP, Hôpital de la Pitié-Salpêtrière, Department of Neurosurgery, Paris, France, Paris, France

The aim of this study is to analyze differences in the hyperdirect cortical connectivity between the subthalamic nucleus and its medial region, and the anatomo-functional organization of these regions using tractography. These analyzes were performed in healthy subjects and parkinsonian patients. Our results show that a dominant motor cluster was located in the posterolateral STN, a limbic cluster located medially in the MSR, and an intermediate motor-limbic cluster located in between for both cohorts. In conclusion, tractography based sub-parcellisation of subthalamic regions could be helpful to refine individual targeting for functional neurosurgery.

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